Molecular Biology and Physiology

Introduction

Hyperresponsiveness in Allergy

Hyperresponsiveness in Allergy

The tissue/organ hyperresponsiveness is a characteristic feature of allergic diseases. For example, people with allergic asthma have non-specific bronchial hyperresponsiveness, causing severe bronchoconstriction even in daily environments with infinitesimal dust, cold air, and so on. People with allergic rhinitis and atopic dermatitis also have nasal and skin hyperresponsiveness, respectively. To date, mechanisms of hyperresponsiveness in allergic diseases are largely unknown. We thus try to understand the underlying mechanism of hyperresponsiveness using animal/cell models of allergic diseases.

Current Research Interests:

  1. Epigenetic/epitranscriptomic changes in non-immune cells in allergy
  2. Epigenetic transgenerational inheritance of allergic susceptibility

TOPへ戻る TOP