Synthetic Biomolecular Chemistry

Introduction

Synthesis of glycoconjugates and modified antibodies by organic chemistry

Synthesis of glycoconjugates and modified antibodies by organic chemistry

Organic chemistry has developed related with biological molecules and events since its beginning. Currently, a strong demand on homogeneous large-molecular weight molecules such as glycosides and glycoconjugates is increasing. Because glycosides/glycoconjugates are not directly encoded to the genome, either preparation or amplification in homogenous form are difficult. We synthesize glycans, glycoproteins, and related biologically active compounds by organic chemistry. Our research topics include:

  1. Development of novel glycosylation reactions and synthesis of biologically active glycosides: We developed stereoselective glycosylation reaction using endocyclic cleavage reaction. We synthesis biologically active oligosaccharides using the stereoselective reaction.
  2. Synthesis of glycoconjugates: Antibody is one of the most widely used biopharmaceuticals. We prepare glycan-modified antibodies by chemo-enzymatic synthesis.
  3. Development of antibody-drug conjugates: Synthetic organic chemistry can contribute to prepare antibody-drug conjugates (ADCs) and radioimmunotherapy (RIT). We investigate strategies for efficient ADC and RIT development.
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