LABORATORIES
Pathophysiology
Faculty
Introduction
Investigation of the molecular and cellular pathobiology of hematological malignancies, osteosarcoma and autoimmune diseases
Investigation of the molecular and cellular pathobiology of hematological malignancies, osteosarcoma and autoimmune diseases
Recent advances in medical science have been bringing great benefits for the patients suffering from cancer and autoimmune disease. However, the majority of osteosarcoma, leukemia and myeloma patients remain incurable because of relapse, metastasis or resistance to therapy. We are focusing our attention on the molecular mechanisms of cancer development with cell lines and our unique disease-model mice. We aim to develop novel therapeutic approaches based on our findings. Furthermore, autoimmune thyroid diseases such as Graves’ disease, caused by thyroid-stimulating antibody, are common and exhibit a variety of clinical manifestations. Using Graves’ disease model mice, we attempt to reveal how the immune disorder and dysfunction in several organs could occur.