Pharmacology

Introduction

Analysis of medical and life science questions and issues together with the latest science and technology

Analysis of medical and life science questions and issues together with the latest science and technology

The Department of Pharmacology at Hoshi University School of Pharmacy is a large department that consists of approximately 130 people, including pharmacists, medical doctors, graduate students, and undergraduate students as well as five faculty members. Our Department is engaged in research activities to elucidate the pathology of intractable diseases such as cranial nerve disease, chronic pain, cancer, and drug dependence, as well as to comprehensively understand the higher-order functions of the brain and develop new therapeutic drugs. Specifically, we are working to clarify the mechanisms of cellular memory and cellular degradation caused by changes in the higher-order structure of genes based on a variety of medical and life science questions and issues. Some of the questions are, for example, “Dose brain dysfunction contribute to the progression of intractable diseases and cancer? Do stress and pain reduce immunity? Do pleasure and exercise enhance immunity? How can damaged tissues and cells be resuscitated?” These studies are based on an analysis of the mechanisms of gene-expression regulation and cell reprogramming, the subclassification of disease cells, analyses of the control of iPS cell differentiation in human disease, and other scientific approaches to regenerative medicine.

The end-point of these studies is the treatment of the cause of refractory disease. In order to carry out such research, we have introduced cutting-edge technologies such as brain nerve-network analysis and brain imaging analysis that combine genetic variants and optogenetic techniques. The Department is a unique and heterogeneous environment where not only students but also active pharmacists, doctors, and veterinarians gather since it is important to consider the results obtained from various perspectives. In addition, we actively provide opportunities for students to acquire specialized knowledge and skills under the leadership of specialists in each field through our links with the National Cancer Research Institute, Keio University School of Medicine, Juntendo University School of Medicine, and other medical faculties and research institutes in Tokyo, as well as with various collaborative research institutes such as the University of Arizona and Stanford University in the United States.

We are constantly working to improve individual skills and keep pace with scientific progress without lowering research hurdles. We will continue to explore the foundations and principles of life science to better comprehend diseases and physiological phenomena from a wide range of perspectives, and aim to train pharmaceutical researchers and pharmacists who can develop therapeutic outcomes.

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