Physiology and Morphology

Introduction

Investigation of mechanisms underlying cardiovascular diseases such as hypertension and diabetes

Investigation of mechanisms underlying cardiovascular diseases such as hypertension and diabetes

Cardiovascular diseases such as atherosclerosis, hypertension, and diabetes mellitus (DM) represent one of the most important causes of morbidity and mortality worldwide. Although vascular dysfunction including restricted relaxation and/or augmented contraction plays an important role in the development of cardiovascular diseases, detailed mechanisms remain unclear. A comprehensive understanding of mechanisms underlying vascular dysfunction in such diseases is needed. For several years, our research has been focused on vascular function in cardiovascular diseases, especially DM.

Our current interests are 1) elucidation of molecular mechanism and/or signal-transduction in vascular function, 2) identification of therapeutic target against disease-associated vasculopathy, and 3) definition of the role of vascular as the network between the vasculature and other organs in animal models of diseases by using pharmacological, physiological, and molecular biology techniques. We believe that our findings provide novel therapeutic targets for the prevention and treatment of cardiovascular diseases.

TOPへ戻る TOP